Randomised Placebo-Controlled Crossover Trial on Effect Ofinactivated Influenza Vaccine on Pulmonary Function in Asthma

1. Nicholson KG, 2. Nguyen-Van-Tam JS, Ahmed AH, et al (1998) Lancet. 351:326–331. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] #### Purpose of the Study Influenza virus infection is a cause of major morbidity each year, especially in patients with chronic disease such as asthma. Although current recommendations are to administer influenza vaccine to children and adults with asthma, compliance is suboptimal because of various reasons including fear that the vaccine itself may trigger an asthma exacerbation. The purpose of this study was to assess the safety of influenza vaccine in patients with asthma. ##### Study Population Two hundred sixty-two patients (114 males and 148 females) ages 18 to 75 years with a history of asthma, defined as recurrent episodes of airway obstruction that resolved on treatment, and whose diagnosis … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DNicholson%26rft.auinit1%253DK.%2BG.%26rft.volume%253D351%26rft.issue%253D9099%26rft.spage%253D326%26rft.epage%253D331%26rft.atitle%253DRandomised%2Bplacebo-controlled%2Bcrossover%2Btrial%2Bon%2Beffect%2Bof%2Binactivated%2Binfluenza%2Bvaccine%2Bon%2Bpulmonary%2Bfunction%2Bin%2Basthma.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252897%252907468-0%26rft_id%253Dinfo%253Apmid%252F9652613%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(97)07468-0&link_type=DOI [3]: /lookup/external-ref?access_num=9652613&link_type=MED&atom=%2Fpediatrics%2F104%2FSupplement_2%2F376.2.atom [4]: /lookup/external-ref?access_num=000071864000012&link_type=ISI