Inhibitors Of Bacterial Enoyl Acyl Carrier Protein Reductase (Fabi): 2,9-Disubstituted 1,2,3,4-Tetrahydropyrido[3,4-B]Indoles As Potential Antibacterial Agents

Ma Seefeld,Wh Miller,Ka Newlander,Wj Burgess,Dj Payne, Sf Rittenhouse,Td Moore, We Dewolf,Pm Keller,Xy Qiu, Ca Janson, K Vaidya, Ap Fosberry, Mg Smyth, Dd Jaworski, C Slater-Radosti, Wf Huffman

Bioorganic & medicinal chemistry letters(2001)

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摘要
An SAR study of a screening lead has led to the identification of 2,9-disubstituted 1, 2, 3, 4-tetrahydropyrido [3,4-b]indoles as inhibitors of Staphylococcus aureus enoyl acyl carrier protein reductase (FabI). (C) 2001 Elsevier Science Ltd. All rights reserved.
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