Aspartyl-(asparaginyl)-β-hydroxylase regulates hepatocellular carcinoma invasiveness

Suzanne M. de la Monte,Seishu Tamaki,M. Chiara Cantarini,Nedim Ince,Marcus Wiedmann,Jade J. Carter,Stephanie A. Lahousse,Sophia Califano,Takashi Maeda,Takato Ueno,Antonia D'Errico,Franco Trevisani,Jack R. Wands

Journal of Hepatology（2006）

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摘要

Conclusions The results suggest that enhanced AAH gene activity is a common feature of human HCC and growth factor signaling through IRS-1 regulates AAH expression and increases motility and invasion of HCC cells. Therefore, AAH may represent an important target for regulating tumor growth in vivo.

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关键词

Hepatocellular carcinoma,Cell motility,Tumor cell invasion, Metastasis

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