Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II

Matthew A. J. Duncton,Evgueni L. Piatnitski,Reeti Katoch-Rouse,Leon M. II Smith,Alexander S. Kiselyov,Daniel L. Milligan,Chris Balagtas,Wai C. Wong,Joel Kawakami,Jacqueline F. Doody

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

The synthesis and structure–activity relationships for a sub-class of arylphthalazine derivatives which have found use as inhibitors of VEGF receptors I and II are reported.

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关键词

Vascular endothelial growth factor,Kinase inhibitor,Angiogenesis,Phthalazine

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