Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists

John A. Wendt,Susan D. Deeter,Susan E. Bove,Christopher S. Knauer,Rachel M. Brooker,Corinne E. Augelli-Szafran,Roy D. Schwarz,Jack J. Kinsora,Kenneth S. Kilgore

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

A novel series of potent 2-aryl pyrido[2,3-d]pyrimidine mGlu5 receptor antagonists are described. The synthesis and pharmacological activities of these analogs are discussed.

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关键词

Pyrido[2,3-d]pyrimidine,Synthesis,SAR,mGlu5 receptor antagonist,Arthritis,Rat

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