OC73: Periventricular Brain Cysts: Fetal Imaging and Postnatal/postmortem Findings

Methods: We considered 58 consecutive single pregnancies referred to our Centre for Prenatal Diagnosis with a lateral ventricle measurement between 9.5 and 9.9 mm. For all cases we obtained perinatal and long-term follow-up (> 24 months). Results: In 14 cases (24%) associated malformations were present: four aneuploidies (two trisomy 21, one trisomy 13 and one triploidy), one complex malformation, three spina bifida with myelomeningocele, one transposition of great arteries, two Beckwith syndromes, one Zellweger syndrome, one case of epilepsy associated with liver dysfunction, one renal pelvic dilatation. Among the 44 cases of isolated ventriculomegaly, one pregnancy was terminated because of psychiatric indication, 42 infants (97%) were healthy at more than 24 months of life, and only one newborn showed severe neurological dysfunction (neurodevelopmental delay and motor deficit) caused by a demyelinating disease of the white matter not diagnosable in utero. Conclusions: These data, comparable to those obtained for ventriculomegaly between 10 and 12 mm, suggest that the cut-off for mild ventriculomegaly should be lowered to 9.5 mm.