2,5-Diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3).

Christopher Lum,Jeff Kahl,Linda Kessler,Jeff Kucharski,Jan Lundström,Stephen Miller,Hiroshi Nakanishi,Yazhong Pei,Kent Pryor,Edward Roberts,Lubomir Sebo,Robert Sullivan,Jan Urban,Zhijun Wang

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

The structure–activity relationships of potent and selective pyrimidine- and azapurine-based inhibitors of glycogen synthase kinase-3 (GSK-3) are reported.

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关键词

Kinase inhibitors,GSK-3,Aurora A,Diabetes,Alzheimer’s,Depression,Bipolar disorder,Molecular modeling

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