DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS

The Hedgehog signaling pathway is implicated in a number of cancers, and synergism with the RAS pathway has been suggested. Now the molecular mechanisms of this interaction are uncovered, revealing that oncogenic RAS shifts Hedgehog signaling to a paracrine mode via its effector kinase DYRK1B.