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Organ selective angiotensin antagonists: Sarcosyl1-cysteinyl(s-methyl)8-angiotensin I

EUROPEAN JOURNAL OF PHARMACOLOGY, no. 4 (1980): 349.0-354.0

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Abstract

An angiotensin antagonist, Sarcosyl1-Cysteinyl(S-Methyl)8-angiotensin I [Sar1-Cys(Me)8-ANG I] was synthesized and its pharmacological properties evaluated in vivo (rat blood pressure assay) and in vitro (rabbit aortic strips, guinea-pig ileum and rat uterus assays). It was found to be an extremely potent angiotensin II (ANG II) antagonist...More

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