Discovery of novel (S)-α-phenyl-γ-amino butanamide containing CCR5 antagonists via functionality inversion approach
Bioorganic & Medicinal Chemistry Letters（2010）
摘要
The (S)-α-phenyl-γ-amino butanamide derivatives display high potency to antagonize CCR5 with nanomolar IC50 values.
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关键词
CCR5 antagonist,HIV-1 entry inhibitor,Functionality inversion,Bioisostere,Butanamide,Tropane,2-Methyl-3H-imidazo[4,5-b]pyridine,3H-[1,2,3]Triazolo[4,5-b]pyridine
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