Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.
Bioorganic & Medicinal Chemistry Letters(2006)
摘要
The structure–activity relationship studies of 1,4-dihydropyridine-3-carboxylic acid derived N-type calcium channel blockers were reported. As a consequence of this study, we found orally active 4-(3-chloro-phenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 5-(3,3-diphenylpropyl) ester (21b).
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关键词
N-type calcium channels blocker,Analgesic,1,4-Dihydropyridine,Cilnidipine,Structure–activity relationship study
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