Design and synthesis of orally bioavailable benzimidazoles as Raf kinase inhibitors.

Savithri Ramurthy,Sharadha Subramanian,Mina Aikawa,Payman Amiri,Abran Costales,Jeff Dove,Susan Fong,Johanna M Jansen,Barry Levine,Sylvia Ma,Christopher M McBride,Jonah Michaelian,Teresa Pick,Daniel J Poon,Sandhya Girish,Cynthia M Shafer,Darrin Stuart,Leonard Sung,Paul A Renhowe

JOURNAL OF MEDICINAL CHEMISTRY（2008）

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摘要

A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure-activity relationship resulted in compounds that are potent in vitro and show desirable in vivo properties.

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