Homogene Strain-Analyse im Vergleich zur Wanddickenzunahme für die MR-tomographische Beurteilung der regionalen Myokardfunktion

Purpose: To compare strain analysis and wall thickening (WT) analysis in differentiating the infarcted, adjacent, and remote zones in a rat model of myocardial infarction (MI). Material and Methods: Three normal (NL) and ten rats subjected to myocardial infarction were imaged on a 4.7T scanner. Gradient-echo and SPAMM-tagged cine images were acquired at three short axis levels of the left ventricle (LV). A homogenous strain analysis (principal strains lambda 1 and lambda 2, displacement D, angle beta and a WT-analysis (mm- and %-thickening) were performed in all slices demonstrating MI. Regional function was compared between infarcted rats (infarcted, adjacent and remote zone) and corresponding regions in the NL rats. Additional segmental analysis was performed in the NL rats for the anterior, lateral, inferior and septal wall. Results: In the NL rats, lambda(1), (greatest radial thickening) was greatest in the lateral and anterior wall. WT-analysis showed a pattern of function similar to lambda(1) however, regional differences using WT-analysis were not significant. lambda(2) (greatest circumferential shortening) was most negative in the anterior wall. D was greatest in the lateral and inferior wall. The angle beta was radially directed in all segments. In the infarcted rats, both strain and WT-analyses revealed significant impairment in function in the infarcted and adjacent zones as compared to NL (p < 0.001). However, only the strain analysis (lambda 1, lambda 2, p < 0.001) detected significant remote myocardial dysfunction. Myocardial function differed significantly between the infarcted and adjacent and between the infarcted and remote regions. Strain analysis (lambda 2, D, beta, p < 0.001) also identified significant functional differences between the adjacent and remote zones, however, no statistically significant differences were found using WT-analysis. Conclusion: Strain analysis is superior to WT-analysis in detecting regional functional variations in NL rats and in discriminating function in the infarcted, adjacent and remote zones post MI.