Synthesis And In-Vitro Profile Of 7-Substituted Quinoline Chromanols As Novel, Nonacidic Ltb(4) Antagonists

H Masamune,R Breslow, Jb Cheng,Mj Conklyn, Jf Eggler, A Marfat, Ls Melvin, Js Pillar, Jt Shirley, Hj Showell, Je Tickner

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1995）

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摘要

The development of novel LTB(4) antagonists from a class of quinolylmethyl LTD(4) antagonists is described. These alpha-methyl quinolylmethyl chromanols were found to have good in vitro activity.

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