Synthesis of a non-peptide analogue of omega-conotoxin MVIIA
TETRAHEDRON LETTERS(1998)
摘要
An efficient synthesis of an alkylphenyl ether based peptidomimetic is described. The compound mimics three key amino acids of omega-conotoxin MVIIA from the cone shell Conus magus and may provide an entry to the design of low molecular weight antagonists of N-type neuronal calcium channels. (C) 1998 Elsevier Science Ltd. All rights reserved.
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关键词
amidines,oxadiazoles,peptide analogues,phenols,N-type neuronal calcium channels
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