Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives

Laura C. Meurer,Paul E. Finke,Karen A. Owens,Nancy N. Tsou,Richard G. Ball,Sander G. Mills,Malcolm MacCoss,Sharon Sadowski,Margaret A. Cascieri,Kwei-Lan Tsao,Gary G. Chicchi,Linda A. Egger,Silvi Luell,Joseph M. Metzger,D. Euan MacIntyre,Nadia M.J. Rupniak,Angela R. Williams,Richard J. Hargreaves

Bioorganic & Medicinal Chemistry Letters（2006）

引用 31|浏览30

暂无评分

摘要

The optimization of a cyclopentane-based hNK1 antagonist scaffold will be discussed in the context of enhanced water-solubility, sub-nanomolar hNK1 binding affinity, and oral activity in two in vivo models.

查看译文

关键词

Neurokinin-1: substance P,NK1 antagonist: cyclopentane-based structure

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要