ChemInform Abstract: Synthesis of Novel Anilinoquinolines as c-fms Inhibitors.

Terrence L. Jr. Smalley,Stanley D. Chamberlain,Wendy Y. Mills,David L. Musso,Sab A. Randhawa,John A. Ray,Vicente Samano,Lloyd Frick

Cheminform（2008）

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摘要

A novel series of potent substituted anilinoquinolines were discovered as c-fms inhibitors. The potency could be manipulated upon modification of the C4 aniline and C7 aryl functionality. Pharmacokinetic analysis identified a metabolically stable analog suitable for further investigative work.

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