Acute lymphoblastic leukaemia cells express CCR7 but not higher amounts of IL-10 after CD40 ligation.

W Luczyński, E Iłendo,O Kovalchuk,M Krawczuk-Rybak,I Malinowska,A Kołtan,T Szczepański,J Wysocka, R Jaworowski,I Olejnik,L Chyczewski,M Matysiak,M Wysocki,D Sońta-Jakimczyk,M Wieczorek

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION（2006）

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摘要

The results show that leukaemia-derived dendritic cells obtained with CD40 ligation express CCR7 - chemokine is involved in migration to lymph nodes and does not produce higher amounts of IL-10, a potent immunosuppressive cytokine. Our preclinical findings could be used in the design of immunotherapy trials for the treatment of children with ALL.

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关键词

cancer vaccine,chemokines,children,cytokines,dendritic cells

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