Efficacy of zoledronate against neuroblastoma.

Paxton V Dickson,John B Hamner, Lindsey A Cauthen,Catherine Y C Ng,M Beth McCarville,Andrew M Davidoff

Surgery（2006）

引用 9|浏览10

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摘要

Zoledronate exhibits significant antitumor activity against human neuroblastoma cells in vitro, prevents development of osteolytic lesions, and restricts tumor growth in a murine model of bone metastasis. These results suggest that clinical investigation of zoledronate or similar bisphosphonates as adjuvant therapy in neuroblastoma patients is warranted.

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