A new chemical tool for exploring the physiological function of the PDE2 isozyme

Robert J. Chambers,Kristin Abrams,Norman Y. Garceau,Ajith V. Kamath,Christopher M. Manley,Susan C. Lilley,Douglas A. Otte,Dennis O. Scott,Alissa L. Sheils,David A. Tess,A. Samuel Vellekoop,Yan Zhang,Kelvin T. Lam

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.

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关键词

Phosphodiesterase,PDE2

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