Development of new chromanol antagonists of leukotriene D4

R.J. Chambers,G.W. Antognoli,J.B. Cheng,A. Marfat,J.S. Pillar,J.T. Shirley,J.W. Watson

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1998）

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摘要

By addressing the issues of potency and metabolism in 3, a new series of LTD, antagonists represented by (+)-26 was developed which is equipotent to clinical LTD, antagonists Zafirlukast (1) and Pranlukast (2). (C) 1998 Elsevier Science Ltd. All rights reserved.

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