P3-016: The APOE-ϵ4 allele does not affect rate of cognitive and functional decline in late-onset Alzheimer's disease (AD): Findings from the U.K. Medical Research Council (MRC) genetic resource for AD

Background: The MRC genetic resource for AD is a powerful genetic association sample for late-onset AD (LOAD). The sample comprises 1501 individuals with probable LOAD and 1645 unrelated healthy age and sex matched controls ascertained in the UK. All cases and controls were diagnosed with the same assessment interview, with a proven positive predictive value of 92-95% for the detection of AD neuropathology. AD cases are well defined in terms of cognition, functional ability, behavioral symptoms, family and medical history.