ChemInform Abstract: Design and Synthesis of 2-Oxo-imidazolidine-4-carboxylic Acid Hydroxyamides as Potent Matrix Metalloproteinase-13 Inhibitors.

A novel series of imidazolidinone-based matrix metalloproteinase (MMP) inhibitors was discovered by structural modification of pyrrolidinone la. Potent inhibition of MMP-13 was exhibited by the analogues having 4-(4-fluorophenoxy)phenyl (4a, IC50 = 3 nM) and 4-(naphth-2-yloxy)phenyl (4h, IC50 = 4 nM) as P1' groups.