Immunomodulation of natural killer activity in children with acute lymphoblastic leukaemia.
European Journal of Cancer and Clinical Oncology(1987)
摘要
Modulation of NK activity of PBLs from ALL patients was studied following exposure to IFN-α, staphylococcal protein A and interleukin-2. Only 52% of ALL patients responded to IFN-α stimulation, where the majority of controls showed positive enhancement of NK activity. Protein A failed to cause a significant stimulation of ALL patient PBLs whereas all controls showed a positive response. The majority of ALL patient and child control PBLs were however able to produce significant levels of IFN-γ (protein A stimulation) and IFN-α (Sendai virus stimulation), although significantly more of both types of interferon could be induced in adult PBL samples. The ability of IL-2 to activate NK activity of ALL PBL samples showed a similar trend to IFN-α stimulation; thus, not all ALL patients showed positive augmentation of Nk activity upon IL-2 stimulation. It is clear from these results that interferons and IL-2 may not necessarily lead to activated NK cytolytic activity, and in the present study approx. 50% of ALL patients failed to respond to lymphokine stimulation.
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