A PreciseInterchromosomal ReciprocalExchangebetweenHot Spotsfor Cleavable
msra
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Materials and Methods
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accompanied by a chromosomal translocation at the aprt locus. the breakpoints in both parental sequences were hot spots for amsacrine stimulated dna cleavage in vitro,and the novel junctions formed were precisely as expected for a mechanism involving reciprocal exchange of topoisomerase h,there was a reciprocal exchange between the aprt gene and an unrelated se quence,amongthe aprt mutationsinducedin confluence-arrested chinese hamster ovary d422 cells by the topoisomerase h poison amsacrine
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