Combined Treatment with Statins and Aminobisphosphonates Extends Longevity in a Mouse Model of Human Premature Aging

Ignacio Varela,Sandrine Pereira,Alejandro P Ugalde,Claire L Navarro,María F Suárez,Pierre Cau,Juan Cadiñanos,Fernando G Osorio,Nicolas Foray,Juan Cobo,Félix de Carlos,Nicolas Lévy,José M P Freije,Carlos López-Otín

Nature medicine（2008）

引用 390|浏览35

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摘要

Statins and aminobisphosphonates inhibit post-translational modifications and membrane accumulation of progerin, the protein that causes Hutchinson-Gilford progeria syndrome, pointing to a potential combination therapy for this disease.

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关键词

Biomedicine,general,Cancer Research,Metabolic Diseases,Infectious Diseases,Molecular Medicine,Neurosciences

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