Voxel-based Morphometry (VBM) in Unilateral Mesial Temporal Lobe Epilepsy (mtle): Volume Loss Beyond the Seizure Onset Zone and Neuropsychological Implications

Recent studies in mTLE showed by means of EEG, MRI and FDG-PET structural or functional abnormalities outside the seizure onset-zone. Recent voxel-based morphometry (VBM)-studies were able to show hippocampal degeneration in mesial temporal lobe epilepsy (mTLE) patients, however, there was also marked extrahippocampal loss of brain volume. This VBM-study aimed to depict volume loss outside the seizure focus and to correlate neuropsychological deficits.