Quinolizidinone Carboxylic Acid Selective M1 Allosteric Modulators: SAR in the Piperidine Series

Scott D. Kuduk,Ronald K. Chang, Christina N. Di Marco,William J. Ray,Lei Ma,Marion Wittmann,Matthew A. Seager,Kenneth A. Koeplinger,Charles D. Thompson,George D. Hartman,Mark T. Bilodeau

Bioorganic & Medicinal Chemistry Letters（2011）

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摘要

SAR study of the piperidine moiety in a series of quinolizidinone carboxylic acid M(1) positive allosteric modulators was examined. While the SAR was generally flat, compounds were identified with high CNS exposure to warrant additional in vivo evaluation.

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关键词

Allosteric,Modulator,Muscarinic,Quinolizidinone

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