Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Emma Black,Jason Breed,Alexander L Breeze,Kevin Embrey,Robert Garcia,Thomas W Gero,Linda Godfrey,Peter W Kenny,Andrew D Morley,Claire A Minshull,Andrew D Pannifer,Jon Read,Amanda Rees,Daniel J Russell,Dorin Toader,Julie Tucker

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.

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关键词

Protein tyrosine phosphatase-1B,Structure-based design

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