Recent Developments In Patient-SpecificImage-Based Modeling Of Hemodynamics

Current challenges in patient-specific computational hemodynamics include validation of the numerical models with in vivo data, the use of numerical models in large clinical studies, and the simulation of blood flow patterns in presence of endovascular devices. This paper summarizes some of the recent advances in each of these research directions. In particular, the following studies are described: validation of blood flow dynamics in carotid arteries using magnetic resonance and Doppler ultrasound, clinical study of rupture of cerebral aneurysms and relationship to intraaneurysmal flow patterns, and simulation of flow alterations into cerebral aneurysms due to implantation of stents and coils. This paper shows that accurate patient-specific hemodynamic models can be constructed from medical image data, and can be used for large clinical studies.