Synthesis and cytotoxicity of novel indirubin-5-carboxamides.
Bioorganic & Medicinal Chemistry（2010）
摘要
A series of indirubin-5-carboxamides was synthesized and evaluated for tumor cell growth inhibitory activity and solubility. Indirubins carrying amide substituents with basic centers show significantly enhanced solubility without loss of bioactivity.
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关键词
Indirubin,Chemical synthesis,Antitumor agents,Protein kinase inhibitors
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