Exposure to the chlorofluorocarbon substitute 2,2-dichloro-1,1,1- trifluoroethane and the anesthetic agent halothane is associated with transient protein adduct formation in the heart.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS(1992)
摘要
Hydrochlorofluorocarbons (HCFCs) that are structural analogues of the anesthetic agent halothane may follow a common pathway of bioactivation and formation of adducts to cellular targets of distinct tissues. Exposure of rats to a single dose of HCFC 123 (2,2-dichloro- 1,1,1-trifluoroethane) or its structural analogue halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) in vivo resulted in the formation of one prominent trifluoroacetylated protein adduct (TFA-protein adduct) in the heart. In contrast, a variety of distinct TFA-protein adducts were formed in the liver and the kidney of the same animals. The TFA-protein adduct in the heart was processed rapidly; t1/2 of the intact TFA-protein adduct was less than 12 h.
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关键词
tris-buffered saline,hydrochlorofluorocarbons,pbs,hcfcs,sds-page,cfcs,chlorofluorocarbons,horseradish peroxidase,hrp,tbs,sodium dodecyl sulfate-polyacrylamide gel electrophoresis,phosphate-buffered saline,central nervous system,cardiovascular system
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