A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies.

Craig Jamieson,Stephanie Basten,Robert A Campbell,Iain A Cumming,Kevin J Gillen,Jonathan Gillespie,Bert Kazemier,Michael Kiczun,Yvonne Lamont,Amanda J Lyons,John K F Maclean,Elizabeth M Moir,John A Morrow,Marianthi Papakosta,Zoran Rankovic,Lynn Smith

Bioorganic & Medicinal Chemistry Letters（2010）

引用 39|浏览18

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摘要

Starting from an HTS hit, the evolution of lead compound 22, a positive allosteric modulator of the AMPA receptor is described using structure based drug design.

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关键词

AMPA receptor,Allosteric modulator,SBDD,Hit-to-lead

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