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Plastic Rearrangements of the Ultrastructure of the Hippocampus in Organotypic Tissue Cultures

Neuroscience and behavioral physiology(2002)

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摘要
Hippocampal cross sections of 7-9 day old rats were explanted onto semipermeable microporous membranes for 14-16 days followed by electron microscopic investigation. Besides the structures typical for adult hippocampus in vivo, substantial ultrastructural signs of metabolism and synaptic connections in explants were revealed: redistribution of polysomes and cisterns of granular endoplasmic reticulum, numerous pinocytotic invaginations, growth cones, somatic filopods, dotted (perforated) contacts, new formation of synapses and vacant postsynaptic sites. The data obtained indicate the active compensatory processes of plasticity, which ensure the maintenance of structure and function of hippocampal tissue in vitro.
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关键词
Tissue Culture,Plastic Rearrangement,Organotypic Tissue Culture
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