A Highly Convergent Synthesis of 2‐Phenyl Quinoline as Dual Antagonists for NK2 and NK3 Receptors

A novel and highly convergent synthesis leading to 2-phenyl-quinolines has been developed. As demonstrated in the preparation of 6-fluoro-3-(3-oxo-piperazin-1-ylmethyl)-2-phenyl-quinoline-4-carboxylic acid [(S)-1-cyclohexyl-ethyl]-amide (8), the method provides fascile access to this class of analogues via the common intermediate 7.