A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews.

Avishag Laish-Farkash,Michael Glikson,Dovrat Brass,Dina Marek-Yagel,Elon Pras,Nathan Dascal,Charles Antzelevitch,Eyal Nof,Haya Reznik,Michael Eldar,David Luria

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY（2010）

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摘要

we describe a new mutation in the HCN4 gene causing symptomatic FSB in 3 unrelated individuals of similar ethnic background that may indicate unexplained FSB in this ethnic group. This profound functional defect is consistent with the symptomatic phenotype.

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关键词

electrophysiology,genetics,heart rate,ion channel

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