802 CHARACTERIZATION OF A MAJOR V3 DUPLICATION IN THE NS5A REGION OF GENOTYPE IB HCV BY QUASISPECIES ANALYSIS IN A FRENCH MULTICENTER STUDY

H. Le Guillou-Guillemette,E. Bouthry,A. Pivert,A. Rosenberg,S. Alain,V. Thibault,F. Abravanel,S. Minjolle-Cha,E. André-Garnier, D. Moradpour,C. Henquell,J.-B. Bour,O. Petsaris,Y. Baazia,P. André,P. Trimoulet, C. Gaudy-Graffln,D. Bettinger,H. Saoudin,E. Schvoerer

Journal of hepatology（2011）

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Abstract

4. the dose-dependent neutralization of HCV infection by CD81 specific antibodies and convalescent serum from a recovered HCV genotype 1 patient. Conclusion: This new ex vivo model allows to support HCV replication. It provides a powerful tool for studying the viral life cycle, the dynamics of viral spread in the native tissue and for evaluating the potency and resistance profile of new antiviral therapies.

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