TOMM40 Variable Length Polymorphism is Associated With Memory Function in Asymptomatic Middle-aged Persons

A TOMM40 polymorphism, a variable length intronic poly T repeat (rs10524523), has been shown to influence age of Alzheimer’s disease (AD) onset (Roses et al., 2009). In this study, we tested the hypothesis that subjects homozygous for TOMM40 short poly T sequences <21 (SPT) would show better performance on measures of learning and memory than those who were homozygous for longer poly T sequences ≥21 (LPT) in middle-aged subjects enrolled in WRAP.