2,7-Diazabicyclo[3.3.0]Octanes As Novel H5-Ht1d Receptor Agonists

Michael G.N. Russell,Margaret S. Beer,Josephine A. Stanton,Bindi Sohal,Russell J. Mortishire-Smith,José L. Castro

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1999）

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摘要

The conformational restriction of a (benzylamino)methyl substituted pyrrolidine to form 2,7-diazabicyclo[3.3.0]octanes has led to a series of compounds with high affinity at the h5-HT1D receptor as well as dramatically increased concentrations in the hepatic portal vein following oral administration. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

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