The endosteum region keeps human leukemic stem cells alive.

Cell Stem Cell(2007)

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摘要
Only a subset of hierarchically arranged, primitive human AML progenitor cells can initiate the disease in transplanted immune-deficient mice. A publication in Nature Biotechnology by Ishikawa et al. (2007) describes a new animal model to study chemotherapy-resistant, quiescent human AML CD34 + CD38 − stem cells, which are retained in the endosteum region.
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stem cell
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