Synthesis and structure based optimization of novel Akt inhibitors.
Bioorganic & Medicinal Chemistry Letters(2008)
摘要
Akt1 X-ray co-crystal structures are utilized to optimize the potency of an HTS hit to a spiroindoline pyrrolopyrimidine. The synthesis and SAR of multiple inhibitor classes, along with the efficacy of one lead compound in a tumor model are presented.
更多查看译文
关键词
Akt,Pyrrolopyrimidine,Spiroindoline,Imidazopiperidine
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要