N-Bromosuccinimide/Dibromodimethylhydantoin in aqueous base: A practical method for the bromination of activated benzoic acids

Joseph Auerbach,Steven A. Weissman,Thomas J. Blacklock,Marshall R. Angeles,Karst Hoogsteen

TETRAHEDRON LETTERS（1993）

引用 126|浏览5

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摘要

A new bromination method employing NBS or dibromodimethylhydantoin in aqueous base is described for the synthesis of 3-bromo-2,6-dimethoxybenzoic acid (1) and other monobrominated alkoxybenzoic acids.

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