Study Of Protein Dynamics Vs. Amyloid Formation

Protein fibril formation has been often associated to manifestation of serious and devastating amyloyd diseases, including Alzheimer and BSA. The main mechanism for the formation of amyloid fibrils is the accumulation of protein aggregates in body's organs.In this paper, we try to compare the dynamical behaviour of two amyloidogenic proteins, the Insulin and the Myoglobin. Insulin has been chosen for its pharmacological extensive use in diabete's therapy, while Myoglobin is used as control, since its dynamics is now largely known. The investigation has been performed through incoherent elastic neutron scattering over a wide temperature range. Our results suggest an enhanced stiffness of Insulin with respect to Myoglobin.