Hydroxamic Acids Designed As Inhibitors of Urease
Letters in drug design & discovery(2009)
Abstract
Urease is an enzyme responsible for the hydrolysis of urea into ammonia and carbamate. Humans infected by urease are exposed to a risk of chronic gastritis or cancer. Urease inhibitors have attracted a great deal of attention for their potential as new anti-ulcer drugs. Here, we describe the synthesis of series of hydroxamic acid compounds designed as inhibitors of urease.
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Key words
Hydroxamic acids,Urease,Gastritis,Inhibitors
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