Physiology and potential application of NKT cells: a minireview.

CD1d-restricted T (NKT) cells are potent regulators or autoimmunity, tumor immunity, and transplantation-related immunity. NKT cells are a subset of innate lymphocytes that recognize endogenous or exogenous glycolipids in file context of CD1d molecules. Recent progress in the research or NKT cells has proved that NKT cells function as a bridge between innate and adaptive immunity in anticancer immunity. I:Furthermore, NKT cells also function as a bridge to tolerance or rejection of grafts in organ transplantation. Harnessing the function a NKT cells, and trying in put it into clinical application hi the treatment of autoimmune disease, anticancer cell immunotherapy. and organ transplantation are the dreams or immunologists. This minireview will focus on the physiology NKT cells and potential clinical application.