CB2 selective sulfamoyl benzamides: Optimization of the amide functionality

Allan J. Goodman,Christopher W. Ajello,Karin Worm,Bertrand Le Bourdonnec,Markku A. Savolainen,Heather O’Hare,Joel A. Cassel,Gabriel J. Stabley,Robert N. DeHaven,Christopher J. LaBuda,Michael Koblish,Patrick J. Little,Bernice L. Brogdon,Steven A. Smith,Roland E. Dolle

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

Isosteric replacement of the amide linkage was investigated. Reversal of the amide functionality led to a series of highly selective CB2 receptor agonists.

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关键词

Cannabinoid,CB1,CB2,Sulfamoyl benzamides,Antiallodynia

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