Arylphthalazines: Identification of a new phthalazine chemotype as inhibitors of VEGFR kinase

Evgueni L. Piatnitski,Matthew A. J. Duncton,Alexander S. Kiselyov,Reeti Katoch-Rouse,Dan Sherman,Daniel L. Milligan,Chris Balagtas,Wai C. Wong,Joel Kawakami,Jacqueline F. Doody

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

The synthesis and structure–activity relationships for a new class of arylphthalazine derivatives, which have found use as inhibitors of VEGFR-2 kinase, are reported.

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关键词

Vascular endothelial growth factor,Kinase inhibitor,Angiogenesis,Phthalazine

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