Dna Cleavage Of Novel Propargylic Sulfones. Enhancement Of Potency Via Intercalating Interaction

Wei-Min Dai,Kin Chiu Fong,Hiroshi Danjo,Sei-ichi Nishimoto,Michael Solow,Wing Leung Mak,Mau Lam Yeung

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1996）

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摘要

A number of novel hydroxy propargylic sulfones 7-15 were synthesized as DNA cleaving agents. Enhancement of DNA cleavage potency was observed with those compounds which could interact with DNA through intercalation of the extended aromatic rings. (C) 1996 Elsevier Science Ltd

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novel propargylic sulfones,dna cleavage,cheminform abstract

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