Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor
Bioorganic & Medicinal Chemistry Letters（2005）
摘要
IC50 (βPDGFR)=61nM; kinase specificity: βPDGFR/Flt-3>100; (dog) F%=38.8; T1/2=10.8h.
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关键词
PDGF receptor tyrosine kinase
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