Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands

Joseph P. Sabatucci,Mark A. Ashwell,Eugene Trybulski,Mary-Margaret O’Donnell,William J. Moore,Douglas C. Harnish,Christopher C. Chadwick

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NF-κB transcriptional activity but are devoid of conventional estrogenic activity.

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关键词

Nuclear factor-κB,Estrogen receptor,Sulfonamide

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